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Pizza Casserole with Biscuits

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overhead shot of a baking dish full of pizza casserole
Quick and easy, this delicious homemade pizza casserole is a fun play on everyone’s favorite food.
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Table of Contents
  1. Pizza Casserole with Biscuits Ingredients
  2. How To Make This Pizza Casserole With Biscuits Recipe
  3. How To Serve
  4. Storage
  5. More Recipes You’ll Love
  6. JUMP TO RECIPE

This delicious pizza casserole with biscuits is a simple family favorite that everyone loves. It’s a hearty and fun spin on classic Italian cuisine that is loaded with the tasty pizza flavors of spicy pepperoni and ooey-gooey cheese.

Everyone loves pizza, and we love any recipe that is a twist on this dish. These pizza muffins and this upside down pizza casserole are two more unique pizza recipes.

overhead shot of a baking dish full of pizza casserole

Pizza Casserole with Biscuits Ingredients

Pizza Casserole raw ingredients that are labeled

You will need: 

  • 1 (16.3-ounce) can Grands! Southern Homestyle Biscuits, 8 big biscuits
  • 1 (14-ounce) jar of pizza sauce
  • 1 teaspoon Italian seasoning, divided
  • 2½ cups shredded mozzarella cheese
  • 5 ounces of pepperoni slices
  • Pinch of red pepper flakes, optional

SUBSTITUTIONS AND ADDITIONS

SAUCE: You can use any brand of pizza sauce that you prefer for this casserole. Likewise, if you have a homemade pizza sauce recipe, that would work as well.

TOPPINGS: Feel free to add any of your favorite pizza toppings and get creative with this casserole. Some of our favorite additions are green peppers, mushrooms, green or black olives, and onions.

MEAT: If you are not a fan of pepperoni, you can switch it out for cooked ground beef or Italian sausage in this biscuit pizza bake.

CHEESE: To make your pizza casserole extra cheesy, add parmesan cheese or cheddar cheese along with the mozzarella.

RED PEPPER FLAKES: Sprinkling your casserole with a pinch of red pepper flakes is an optional addition that will give the dish a nice kick.

How To Make This Pizza Casserole With Biscuits Recipe

STEP ONE: Preheat the oven to 375°F. Spray a 9×13-inch casserole dish with nonstick cooking spray.

STEP TWO: Cut each biscuit into 8 pieces.

OUR RECIPE DEVELOPER SAYS

A pizza cutter sprayed with nonstick spray makes slicing the sticky dough much easier.

biscuits cut into pieces on a wooden board

Spread the cut biscuit pieces in the greased casserole dish.

pieces of biscuits spread in a baking dish

STEP THREE: Pour half of the jar of pizza sauce and ½ teaspoon of Italian seasoning over the biscuits. Stir to thoroughly coat all the biscuit pieces with a bit of sauce.

pieces of biscuits topped with pizza sauce and Italian seasoning in a baking dish

STEP FOUR: Sprinkle about 1 cup of the cheese over the biscuit mixture and stir again to distribute evenly.

biscuits topped with shredded cheese in a baking dish

STEP FIVE: Pour the remaining pizza sauce over the biscuit mixture.

pizza sauce poured over the biscuits in a baking dish

STEP SIX: Top with the remaining cheese and pepperoni. You may not need or want to use all of it, but you can for an extra cheesy dish.

pizza topped with shredded cheese and pepperoni slices in a baking dish

STEP SEVEN: Sprinkle red pepper flakes and the remaining ½ teaspoon of Italian seasoning over the casserole.

red pepper flakes and Italian seasoning sprinkled on top of the casserole in a baking dish

STEP EIGHT: Bake for 20 to 25 minutes or until the biscuits have puffed and the cheese is melted and beginning to turn golden brown.

pizza casserole after being baked in a baking dish

STEP NINE: Remove from the oven and serve immediately.

PRO TIP:

Serve a slice of this casserole with a bowl of extra pizza sauce for dipping.

How To Serve

Change up pizza night with this cheesy casserole. Serve it alongside a crisp, fresh Caesar salad and garlic bread and you have a full meal that the whole family will enjoy.

Storage

IN THE FRIDGE: Store leftover pepperoni pizza biscuit casserole covered in plastic wrap for 2 to 3 days in the refrigerator. 

IN THE FREEZER: You can keep leftovers of this easy pepperoni pizza casserole wrapped in an airtight container for up to 3 months in the freezer.

close shot of a baking dish full of pizza casserole with a piece being picked up with a wooden spoon

This one-dish meal is the perfect dinner option for busy weeknights. Add any of your favorite pizza toppings to make this just the way your family likes it. In under an hour, you’ll have a filling, saucy, and cheesy dish that no one will turn down.

FREQUENTLY ASKED QUESTIONS

Can I freeze the leftovers of this casserole?

Leftovers of this pizza casserole can be frozen in an airtight container for up to three months.

Can I add other pizza toppings to this dish?

You can add any of your favorite pizza toppings into this casserole if you’d like. Vegetables such as mushrooms, peppers, onions, and olives are all delicious choices.

Can I make this dish ahead of time?

You could assemble this dish the night before and keep it covered in the fridge until you are ready to bake it the next day.

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overhead shot of a baking dish full of pizza casserole

Pizza Casserole with Biscuits

5 from 1 vote
Quick and easy, this delicious homemade pizza casserole is a fun play on everyone’s favorite food.
Prep Time 10 minutes
Cook Time 25 minutes
Total Time 35 minutes
Servings 9

Ingredients
  

  • 16.3 ounces Grands! Southern Homestyle Biscuits (8 big biscuits)
  • 14 ounces pizza sauce
  • 1 teaspoon Italian seasoning, divided
  • cup shredded mozzarella cheese
  • 5 ounces pepperoni slices
  • 1 pinch red pepper flakes, optional

Instructions
 

  • Preheat the oven to 375°F. 
  • Cut each biscuit into 8 pieces.
  • Spread biscuit pieces in a greased 9×13 casserole dish.
  • Pour ½ of the jar of pizza sauce and ½ teaspoon Italian seasoning over biscuits. Then stir to thoroughly coat all the biscuit pieces with a bit of sauce.
  • Sprinkle about 1 cup of the cheese over the biscuit mixture and stir again to distribute evenly.
  • Pour the remaining pizza sauce over the biscuit mixture.
  • Top with the remaining cheese and pepperoni. You may not need or want to use all of it, but you can for an extra cheesy dish.
  • Sprinkle red pepper flakes (desired amount) and remaining ½ teaspoon of Italian seasoning over top of the casserole.
  • Bake for 20 to 25 minutes or until the biscuits have puffed and the cheese is melted and beginning to brown.
  • Remove from oven and serve immediately.

Notes

  • A pizza cutter sprayed with nonstick spray makes slicing the sticky dough much easier.
  • Serve a slice of this casserole with a bowl of extra pizza sauce for dipping.

Nutrition

Calories: 370kcal | Carbohydrates: 28g | Protein: 14g | Fat: 22g | Saturated Fat: 8g | Cholesterol: 42mg | Sodium: 1187mg | Potassium: 329mg | Fiber: 1g | Sugar: 4g | Vitamin A: 401IU | Vitamin C: 3mg | Calcium: 195mg | Iron: 3mg
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