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Pizza Casserole with Biscuits

overhead shot of a baking dish full of pizza casserole
Quick and easy, this delicious homemade pizza casserole is a fun play on everyone’s favorite food.
Prep Time 10 mins
Cook Time 25 mins
Total Time 35 mins
Course Main Course
Cuisine American, Italian
Servings 9
Calories 370 kcal


  • 16.3 ounces Grands! Southern Homestyle Biscuits (8 big biscuits)
  • 14 ounces pizza sauce
  • 1 teaspoon Italian seasoning, divided
  • cup shredded mozzarella cheese
  • 5 ounces pepperoni slices
  • 1 pinch red pepper flakes, optional


  • Preheat the oven to 375°F. 
  • Cut each biscuit into 8 pieces.
  • Spread biscuit pieces in a greased 9x13 casserole dish.
  • Pour ½ of the jar of pizza sauce and ½ teaspoon Italian seasoning over biscuits. Then stir to thoroughly coat all the biscuit pieces with a bit of sauce.
  • Sprinkle about 1 cup of the cheese over the biscuit mixture and stir again to distribute evenly.
  • Pour the remaining pizza sauce over the biscuit mixture.
  • Top with the remaining cheese and pepperoni. You may not need or want to use all of it, but you can for an extra cheesy dish.
  • Sprinkle red pepper flakes (desired amount) and remaining ½ teaspoon of Italian seasoning over top of the casserole.
  • Bake for 20 to 25 minutes or until the biscuits have puffed and the cheese is melted and beginning to brown.
  • Remove from oven and serve immediately.


  • A pizza cutter sprayed with nonstick spray makes slicing the sticky dough much easier.
  • Serve a slice of this casserole with a bowl of extra pizza sauce for dipping.


Sodium: 1187mgCalcium: 195mgVitamin C: 3mgVitamin A: 401IUSugar: 4gFiber: 1gPotassium: 329mgCholesterol: 42mgCalories: 370kcalSaturated Fat: 8gFat: 22gProtein: 14gCarbohydrates: 28gIron: 3mg