pizza casserole recipe

Pizza Casserole

Hearty and delicious, this homemade pizza casserole combines tender pasta, lots of cheese, ground beef, seasoning, and pepperoni into a yummy meal.
Course Main Course
Cuisine American, Italian
Keyword Pizza Casserole, Pizza Casserole Recipe
Prep Time 10 minutes
Cook Time 30 minutes
Total Time 40 minutes
Servings 8
Calories 543kcal


  • 1 pound ground beef
  • Salt and pepper to taste
  • ½ tablespoon olive oil
  • ½ cup onion
  • 1 teaspoon minced garlic
  • 2 cups shredded mozzarella cheese divided
  • 16 ounces Rotini or Penne pasta uncooked
  • 24 ounce spaghetti or marinara sauce
  • 1 tablespoon Italian seasoning
  • 1 cup pepperoni
  • ½ teaspoon Italian seasoning
  • Fresh shredded parmesan for garnish optional


  • Preheat oven to 350 degrees. Spray a 9x13 pan with nonstick spray.
  • Cook pasta according to directions on package for al dente, drain and set aside.
  • In a LARGE skillet add the olive oil and cook the ground beef, onions and garlic, all seasoned with salt and pepper, until no pink remains in the meat. Drain any extra grease.
  • Add the spaghetti sauce and Italian seasoning to the ground beef and stir to heat. Remove from heat.
  • Add the cooked pasta and 1 cup of cheese to the meat and stir to mix.
  • Pour into the prepared 9x13 pan and spread evenly in the pan.
  • Top with remaining 1 cup of cheese.
  • Lay the slices of pepperoni on top of the cheese.
  • Sprinkle with ½ teaspoon Italian seasoning.
  • Bake for 25-30 minutes, uncovered.


Calories: 543kcal | Carbohydrates: 49g | Protein: 28g | Fat: 26g | Saturated Fat: 10g | Cholesterol: 77mg | Sodium: 912mg | Potassium: 644mg | Fiber: 4g | Sugar: 6g | Vitamin A: 568IU | Vitamin C: 7mg | Calcium: 192mg | Iron: 3mg